Barza M, Cuchural G. Drug concentration in the blood plasma, serum has been correlated to in vivo bacterial eradication. J Infect. Chambers HF, Kennedy S. The ability of a drug to do so depends on tissue-related factors such as perfusion to the tissues, the surface area of the tissue's vascular bed, and specialized vascular bed features, such as tight junctions or capillary pores and drug-related factors such as lipid solubility, molecular size, the drug's pKa, and plasma protein binding. Also, because the drug will have to be diluted in a relative small volume, bolus infusion will expose the vein through which the drug is infused to high drug concentrations that may limit the use of bolus infusion because of venous irritation and pain. Toxic side effects may occur as plasma and tissue drug concentrations increase.
Time-Dependent vs. Concentration-Dependent Killing. Richard Quintiliani, M.D.
Video: Ampicillin time or concentration dependent Pharmacokinetics 1 - Introduction
Pharmacokinetics deals with the movement of a drug from its administration site. Only 30% to 55% of an oral ampicillin dose is absorbed. The area under the plasma concentration versus time curve (AUC, for “area under the curve”) is .
Pharmacodynamics of Antimicrobial Agents TimeDependent vs. ConcentrationDependent Killing
The second group includes drugs that exhibit concentration-dependent bactericidal. In addition to drugs that are time-dependent or concentration-dependent, a third category exhibits both effects; the new agent tigecycline.
J Lab Clin Med. Open in a separate window. The pharmacodynamics of aminoglycosides. Oral Administration A few antibacterial agents have excellent bioavailability after oral administration.
Therefore, despite apparently adequate total plasma levels of highly protein-bound drugs, the concentration of free ie, active drug might be less than the MIC of the pathogen, which will necessitate the use of higher doses.
PK/PD Approach to Antibiotic Therapy Review
Med Clin North Am.
Ampicillin, Listeria monocytogenes +++, Escherichia coli +, Genitourinary tract. Time course of systemic drug concentration following drug administration. MIC: Mimimal Inhibitory Concentration. Inset: Illustrates how the MIC.
Additionally, antibiotics that have both concentration- and time-dependent penicillins (e.g., oxacillin, ampicillin/sulbactam, piperacillin/tazobactam), 50%.
Concentration-Dependent Killing: Other classes of antibiotics, such as aminoglycosides and quinolones, have high concentrations at the binding site which eradicates the microorganism and, hence, these drugs are considered to have a different kind of bacterial killing, named concentration-dependent killing.
Distribution Distribution is the process by which a drug diffuses from the intravascular fluid space to extravascular fluid spaces, and it is best described by the drug's volume of distribution.
Pharmacokinetics and Pharmacodynamics of Antibacterial Agents
CMS undergoes rapid hydrolysis in vivo to colistin, the bioactive drug. Pharmacokinetic and pharmacodynamic issues in the treatment of parasitic infections.
Video: Ampicillin time or concentration dependent How antibiotics work
Arch Intern Med. Theoretically, at equilibrium, free-drug levels in plasma and extracellular tissue fluid should be equal.